Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
Identifieur interne : 002C49 ( Main/Exploration ); précédent : 002C48; suivant : 002C50Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
Auteurs : Valentina Escott-Price [Royaume-Uni] ; Céline Bellenguez [France] ; Li-San Wang [États-Unis] ; Seung-Hoan Choi [États-Unis] ; Denise Harold [Royaume-Uni] ; Lesley Jones [Royaume-Uni] ; Peter Holmans [Royaume-Uni] ; Amy Gerrish [Royaume-Uni] ; Alexey Vedernikov [Royaume-Uni] ; Alexander Richards [Royaume-Uni] ; Anita L. Destefano [États-Unis] ; Jean-Charles Lambert [France] ; Carla A. Ibrahim-Verbaas [Pays-Bas] ; Adam C. Naj [États-Unis] ; Rebecca Sims [Royaume-Uni] ; Gyungah Jun [États-Unis] ; Joshua C. Bis [États-Unis] ; Gary W. Beecham [États-Unis] ; Benjamin Grenier-Boley [France] ; Giancarlo Russo [Suisse] ; Tricia A. Thornton-Wells [États-Unis] ; Nicola Denning [Royaume-Uni] ; Albert V. Smith [Islande] ; Vincent Chouraki [France, États-Unis] ; Charlene Thomas [Royaume-Uni] ; M. Arfan Ikram [Pays-Bas] ; Diana Zelenika [France] ; Badri N. Vardarajan [États-Unis] ; Yoichiro Kamatani [France] ; Chiao-Feng Lin [États-Unis] ; Helena Schmidt [Autriche] ; Brian Kunkle [États-Unis] ; Melanie L. Dunstan [Royaume-Uni] ; Maria Vronskaya [Royaume-Uni] ; Andrew D. Johnson [États-Unis] ; Agustin Ruiz [Espagne] ; Marie-Thérèse Bihoreau [France] ; Christiane Reitz [États-Unis] ; Florence Pasquier [France] ; Paul Hollingworth [Royaume-Uni] ; Olivier Hanon [France] ; Annette L. Fitzpatrick [États-Unis] ; Joseph D. Buxbaum [États-Unis] ; Dominique Campion [France] ; Paul K. Crane [États-Unis] ; Clinton Baldwin [États-Unis] ; Tim Becker [Allemagne] ; Vilmundur Gudnason [Islande] ; Carlos Cruchaga [États-Unis] ; David Craig [Royaume-Uni] ; Najaf Amin [Pays-Bas] ; Claudine Berr [France] ; Oscar L. Lopez [États-Unis] ; Philip L. De Jager [États-Unis] ; Vincent Deramecourt [France] ; Janet A. Johnston [Royaume-Uni] ; Denis Evans [États-Unis] ; Simon Lovestone ; Luc Letenneur [France] ; Isabel Hernández [Espagne] ; David C. Rubinsztein [Royaume-Uni] ; Gudny Eiriksdottir [Islande] ; Kristel Sleegers [Belgique] ; Alison M. Goate [États-Unis] ; Nathalie Fiévet [France] ; Matthew J. Huentelman [États-Unis] ; Michael Gill [Irlande (pays)] ; Kristelle Brown [Royaume-Uni] ; M. Ilyas Kamboh [États-Unis] ; Lina Keller [Suède] ; Pascale Barberger-Gateau ; Bernadette Mcguinness [Royaume-Uni] ; Eric B. Larson [États-Unis] ; Amanda J. Myers [États-Unis] ; Carole Dufouil [France] ; Stephen Todd [Royaume-Uni] ; David Wallon [France] ; Seth Love [Royaume-Uni] ; Ekaterina Rogaeva [Canada] ; John Gallacher [Royaume-Uni] ; Peter St George-Hyslop [Canada, Royaume-Uni] ; Jordi Clarimon [Espagne] ; Alberto Lleo [Espagne] ; Anthony Bayer [Royaume-Uni] ; Debby W. Tsuang [États-Unis] ; Lei Yu [États-Unis] ; Magda Tsolaki [Grèce] ; Paola Bossù [Italie] ; Gianfranco Spalletta [Italie] ; Petra Proitsi ; John Collinge [Royaume-Uni] ; Sandro Sorbi [Italie] ; Florentino Sanchez Garcia [Espagne] ; Nick C. Fox [Royaume-Uni] ; John Hardy [Royaume-Uni] ; Maria Candida Deniz Naranjo [Espagne] ; Paolo Bosco [Italie] ; Robert Clarke [Royaume-Uni] ; Carol Brayne [Royaume-Uni] ; Daniela Galimberti [Italie] ; Elio Scarpini [Italie] ; Ubaldo Bonuccelli [Italie] ; Michelangelo Mancuso [Italie] ; Gabriele Siciliano [Italie] ; Susanne Moebus [Allemagne] ; Patrizia Mecocci [Italie] ; Maria Del Zompo [Italie] ; Wolfgang Maier [Allemagne] ; Harald Hampel [Allemagne] ; Alberto Pilotto [Italie] ; Ana Frank-García [Espagne] ; Francesco Panza [Italie] ; Vincenzo Solfrizzi [Italie] ; Paolo Caffarra [Italie] ; Benedetta Nacmias [Italie] ; William Perry [États-Unis] ; Manuel Mayhaus [Allemagne] ; Lars Lannfelt [Suède] ; Hakon Hakonarson [États-Unis] ; Sabrina Pichler [Allemagne] ; Minerva M. Carrasquillo [États-Unis] ; Martin Ingelsson [Suède] ; Duane Beekly [États-Unis] ; Victoria Alvarez [Espagne] ; Fanggeng Zou [États-Unis] ; Otto Valladares [États-Unis] ; Steven G. Younkin [États-Unis] ; Eliecer Coto [Espagne] ; Kara L. Hamilton-Nelson [États-Unis] ; Wei Gu [Allemagne] ; Cristina Razquin [Espagne] ; Pau Pastor [Espagne] ; Ignacio Mateo [Espagne] ; Michael J. Owen [Royaume-Uni] ; Kelley M. Faber [États-Unis] ; Palmi V. Jonsson [Islande] ; Onofre Combarros [Espagne] ; Michael C. O'Donovan [Royaume-Uni] ; Laura B. Cantwell [États-Unis] ; Hilkka Soininen [Finlande] ; Deborah Blacker [États-Unis] ; Simon Mead [Royaume-Uni] ; Thomas H. Mosley [États-Unis] ; David A. Bennett [États-Unis] ; Tamara B. Harris [États-Unis] ; Laura Fratiglioni [Suède] ; Clive Holmes [Royaume-Uni] ; Renee F. A. G. De Bruijn [Pays-Bas] ; Peter Passmore [Royaume-Uni] ; Thomas J. Montine [États-Unis] ; Karolien Bettens [Belgique] ; Jerome I. Rotter [États-Unis] ; Alexis Brice [France] ; Kevin Morgan [Royaume-Uni] ; Tatiana M. Foroud [États-Unis] ; Walter A. Kukull [États-Unis] ; Didier Hannequin [France] ; John F. Powell ; Michael A. Nalls [États-Unis] ; Karen Ritchie [France, Royaume-Uni] ; Kathryn L. Lunetta [États-Unis] ; John S. K. Kauwe [États-Unis] ; Eric Boerwinkle [États-Unis] ; Matthias Riemenschneider [Allemagne] ; Mercè Boada [Espagne] ; Mikko Hiltunen [Finlande] ; Eden R. Martin [États-Unis] ; Reinhold Schmidt [Autriche] ; Dan Rujescu [Allemagne] ; Jean-François Dartigues [France] ; Richard Mayeux [États-Unis] ; Christophe Tzourio [France] ; Albert Hofman [Pays-Bas] ; Markus M. Nöthen [Allemagne] ; Caroline Graff [Suède] ; Bruce M. Psaty [États-Unis] ; Jonathan L. Haines [États-Unis] ; Mark Lathrop [États-Unis, France, Canada] ; Margaret A. Pericak-Vance [États-Unis] ; Lenore J. Launer [États-Unis] ; Christine Van Broeckhoven [Belgique] ; Lindsay A. Farrer [États-Unis] ; Cornelia M. Van Duijn [Pays-Bas] ; Alfredo Ramirez [Allemagne] ; Sudha Seshadri [États-Unis] ; Gerard D. Schellenberg [États-Unis] ; Philippe Amouyel [France] ; Julie Williams [Royaume-Uni]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Carrier Proteins, Heat-Shock Proteins, Receptors, Antigen, B-Cell.
- genetics : Alzheimer Disease.
- Case-Control Studies, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide.
Abstract
Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (
The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
Url:
DOI: 10.1371/journal.pone.0094661
PubMed: 24922517
PubMed Central: 4055488
Affiliations:
- Allemagne, Autriche, Belgique, Canada, Espagne, Finlande, France, Grèce, Irlande (pays), Islande, Italie, Pays-Bas, Royaume-Uni, Suisse, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Aquitaine, Arizona, Bavière, Californie, Canton de Zurich, Catalogne, Communauté de Madrid, District de Cologne, District de Haute-Bavière, East Middle Sweden, Floride, Grand Londres, Haute-Normandie, Hauts-de-France, Hollande-Méridionale, Illinois, Indiana, Languedoc-Roussillon, Latium, Lombardie, Maryland, Massachusetts, Missouri (État), Nord-Pas-de-Calais, Nottinghamshire, Nouvelle-Aquitaine, Occitanie (région administrative), Ohio, Ontario, Oxfordshire, Pennsylvanie, Province d'Anvers, Québec, Rhénanie-du-Nord-Westphalie, Région Normandie, Région flamande, Svealand, Tennessee, Texas, Toscane, Utah, Washington (État), État de New York, État du Mississippi, Île-de-France
- Anvers, Barcelone, Bonn, Bordeaux, Cambridge, Leyde, Lille, Londres, Madrid, Milan, Montpellier, Montréal, Munich, New York, Nottingham, Oxford, Paris, Pise, Pittsburgh, Rome, Rotterdam, Rouen, Saint-Louis (Missouri), Seattle, Stockholm, Toronto, Uppsala, Zurich, Évry (Essonne)
- Université Columbia, Université Lille 2, Université Louis-et-Maximilien de Munich, Université Pierre-et-Marie-Curie, Université autonome de Barcelone, Université d'Anvers, Université d'Oxford, Université d'Uppsala, Université de Cambridge, Université de Nottingham, Université de Pise, Université de Pittsburgh, Université de Toronto, Université de Washington, Université de Zurich, École de médecine (Université Washington de Saint-Louis)
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Le document en format XML
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sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Harold, Denise" sort="Harold, Denise" uniqKey="Harold D" first="Denise" last="Harold">Denise Harold</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country 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Destefano</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Inserm U744, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Université Lille 2, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name><affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>Department of Epidemiology and Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology and Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Naj, Adam C" sort="Naj, Adam C" uniqKey="Naj A" first="Adam C." last="Naj">Adam C. Naj</name><affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Sims, Rebecca" sort="Sims, Rebecca" uniqKey="Sims R" first="Rebecca" last="Sims">Rebecca Sims</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff9"><addr-line>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation wicri:level="4"><nlm:aff id="aff11"><addr-line>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W." last="Beecham">Gary W. Beecham</name><affiliation wicri:level="2"><nlm:aff id="aff12"><addr-line>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff13"><addr-line>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Inserm U744, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Université Lille 2, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Russo, Giancarlo" sort="Russo, Giancarlo" uniqKey="Russo G" first="Giancarlo" last="Russo">Giancarlo Russo</name><affiliation wicri:level="4"><nlm:aff id="aff14"><addr-line>Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Functional Genomics Center Zurich, ETH/University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Thornton Wells, Tricia A" sort="Thornton Wells, Tricia A" uniqKey="Thornton Wells T" first="Tricia A." last="Thornton-Wells">Tricia A. Thornton-Wells</name><affiliation wicri:level="2"><nlm:aff id="aff15"><addr-line>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Denning, Nicola" sort="Denning, Nicola" uniqKey="Denning N" first="Nicola" last="Denning">Nicola Denning</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:aff id="aff16"><addr-line>University of Iceland, Faculty of Medicine, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Icelandic Heart Association, Kopavogur, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Inserm U744, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Université Lille 2, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff18"><addr-line>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Thomas, Charlene" sort="Thomas, Charlene" uniqKey="Thomas C" first="Charlene" last="Thomas">Charlene Thomas</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name><affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff20"><addr-line>Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name><affiliation wicri:level="3"><nlm:aff id="aff21"><addr-line>Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N." last="Vardarajan">Badri N. Vardarajan</name><affiliation wicri:level="2"><nlm:aff id="aff9"><addr-line>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff27"><addr-line>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff28"><addr-line>Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Kamatani, Yoichiro" sort="Kamatani, Yoichiro" uniqKey="Kamatani Y" first="Yoichiro" last="Kamatani">Yoichiro Kamatani</name><affiliation wicri:level="3"><nlm:aff id="aff22"><addr-line>Fondation Jean Dausset- CEPH, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Jean Dausset- CEPH, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lin, Chiao Feng" sort="Lin, Chiao Feng" uniqKey="Lin C" first="Chiao-Feng" last="Lin">Chiao-Feng Lin</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Kunkle, Brian" sort="Kunkle, Brian" uniqKey="Kunkle B" first="Brian" last="Kunkle">Brian Kunkle</name><affiliation wicri:level="2"><nlm:aff id="aff12"><addr-line>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Dunstan, Melanie L" sort="Dunstan, Melanie L" uniqKey="Dunstan M" first="Melanie L." last="Dunstan">Melanie L. Dunstan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Vronskaya, Maria" sort="Vronskaya, Maria" uniqKey="Vronskaya M" first="Maria" last="Vronskaya">Maria Vronskaya</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name><affiliation wicri:level="2"><nlm:aff id="aff25"><addr-line>NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustin" last="Ruiz">Agustin Ruiz</name><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bihoreau, Marie Therese" sort="Bihoreau, Marie Therese" uniqKey="Bihoreau M" first="Marie-Thérèse" last="Bihoreau">Marie-Thérèse Bihoreau</name><affiliation wicri:level="3"><nlm:aff id="aff21"><addr-line>Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Reitz, Christiane" sort="Reitz, Christiane" uniqKey="Reitz C" first="Christiane" last="Reitz">Christiane Reitz</name><affiliation wicri:level="2"><nlm:aff id="aff27"><addr-line>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff28"><addr-line>Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Université Lille 2, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff29"><addr-line>CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Hollingworth, Paul" sort="Hollingworth, Paul" uniqKey="Hollingworth P" first="Paul" last="Hollingworth">Paul Hollingworth</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Hanon, Olivier" sort="Hanon, Olivier" uniqKey="Hanon O" first="Olivier" last="Hanon">Olivier Hanon</name><affiliation wicri:level="3"><nlm:aff id="aff30"><addr-line>University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics department, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics department, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L." last="Fitzpatrick">Annette L. Fitzpatrick</name><affiliation wicri:level="4"><nlm:aff id="aff11"><addr-line>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff31"><addr-line>Departments of Epidemiology and Global Health, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Epidemiology and Global Health, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name><affiliation wicri:level="2"><nlm:aff id="aff32"><addr-line>Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mount Sinai School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff33"><addr-line>Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Mount Sinai School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff34"><addr-line>Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><affiliation wicri:level="3"><nlm:aff id="aff35"><addr-line>CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Crane, Paul K" sort="Crane, Paul K" uniqKey="Crane P" first="Paul K." last="Crane">Paul K. Crane</name><affiliation wicri:level="4"><nlm:aff id="aff36"><addr-line>Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Baldwin, Clinton" sort="Baldwin, Clinton" uniqKey="Baldwin C" first="Clinton" last="Baldwin">Clinton Baldwin</name><affiliation wicri:level="2"><nlm:aff id="aff9"><addr-line>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name><affiliation wicri:level="3"><nlm:aff id="aff37"><addr-line>German Center for Neurodegenerative Diseases (DZNE), Bonn, and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn, and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="aff16"><addr-line>University of Iceland, Faculty of Medicine, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Icelandic Heart Association, Kopavogur, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name><affiliation wicri:level="4"><nlm:aff id="aff38"><addr-line>Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Craig, David" sort="Craig, David" uniqKey="Craig D" first="David" last="Craig">David Craig</name><affiliation wicri:level="1"><nlm:aff id="aff39"><addr-line>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="3"><nlm:aff id="aff40"><addr-line>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation wicri:level="3"><nlm:aff id="aff41"><addr-line>INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name><affiliation wicri:level="2"><nlm:aff id="aff42"><addr-line>Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L." last="De Jager">Philip L. De Jager</name><affiliation wicri:level="2"><nlm:aff id="aff43"><addr-line>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff44"><addr-line>Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Université Lille 2, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff29"><addr-line>CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Johnston, Janet A" sort="Johnston, Janet A" uniqKey="Johnston J" first="Janet A." last="Johnston">Janet A. Johnston</name><affiliation wicri:level="1"><nlm:aff id="aff39"><addr-line>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name><affiliation wicri:level="2"><nlm:aff id="aff45"><addr-line>Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation><nlm:aff id="aff46"><addr-line>King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom</addr-line></nlm:aff><wicri:noCountry code="subfield">United Kingom</wicri:noCountry></affiliation></author><author><name sortKey="Letenneur, Luc" sort="Letenneur, Luc" uniqKey="Letenneur L" first="Luc" last="Letenneur">Luc Letenneur</name><affiliation wicri:level="1"><nlm:aff id="aff47"><addr-line>Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><wicri:noRegion>33076, Bordeaux</wicri:noRegion><wicri:noRegion>33076, Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez, Isabel" sort="Hernandez, Isabel" uniqKey="Hernandez I" first="Isabel" last="Hernández">Isabel Hernández</name><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rubinsztein, David C" sort="Rubinsztein, David C" uniqKey="Rubinsztein D" first="David C." last="Rubinsztein">David C. Rubinsztein</name><affiliation wicri:level="4"><nlm:aff id="aff48"><addr-line>Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Institute for Medical Research, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Icelandic Heart Association, Kopavogur, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name><affiliation wicri:level="1"><nlm:aff id="aff49"><addr-line>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff50"><addr-line>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Goate, Alison M" sort="Goate, Alison M" uniqKey="Goate A" first="Alison M." last="Goate">Alison M. Goate</name><affiliation wicri:level="4"><nlm:aff id="aff38"><addr-line>Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Inserm U744, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Huentelman, Matthew J" sort="Huentelman, Matthew J" uniqKey="Huentelman M" first="Matthew J." last="Huentelman">Matthew J. Huentelman</name><affiliation wicri:level="2"><nlm:aff id="aff51"><addr-line>Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name><affiliation wicri:level="1"><nlm:aff id="aff52"><addr-line>Discipline of Psychiatry, Trinity College, Dublin, Ireland</addr-line></nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Discipline of Psychiatry, Trinity College, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Kristelle" sort="Brown, Kristelle" uniqKey="Brown K" first="Kristelle" last="Brown">Kristelle Brown</name><affiliation wicri:level="4"><nlm:aff id="aff53"><addr-line>Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name><affiliation wicri:level="4"><nlm:aff id="aff54"><addr-line>Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff55"><addr-line>Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Keller, Lina" sort="Keller, Lina" uniqKey="Keller L" first="Lina" last="Keller">Lina Keller</name><affiliation wicri:level="3"><nlm:aff id="aff56"><addr-line>Aging Reasearch Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Aging Reasearch Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Barberger Gateau, Pascale" sort="Barberger Gateau, Pascale" uniqKey="Barberger Gateau P" first="Pascale" last="Barberger-Gateau">Pascale Barberger-Gateau</name><affiliation><nlm:aff id="aff46"><addr-line>King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom</addr-line></nlm:aff><wicri:noCountry code="subfield">United Kingom</wicri:noCountry></affiliation></author><author><name sortKey="Mcguinness, Bernadette" sort="Mcguinness, Bernadette" uniqKey="Mcguinness B" first="Bernadette" last="Mcguinness">Bernadette Mcguinness</name><affiliation wicri:level="1"><nlm:aff id="aff39"><addr-line>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B." last="Larson">Eric B. Larson</name><affiliation wicri:level="4"><nlm:aff id="aff36"><addr-line>Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff57"><addr-line>Group Health Research Institute, Group Health, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Group Health, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Myers, Amanda J" sort="Myers, Amanda J" uniqKey="Myers A" first="Amanda J." last="Myers">Amanda J. Myers</name><affiliation wicri:level="2"><nlm:aff id="aff58"><addr-line>Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><affiliation wicri:level="3"><nlm:aff id="aff47"><addr-line>Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Todd, Stephen" sort="Todd, Stephen" uniqKey="Todd S" first="Stephen" last="Todd">Stephen Todd</name><affiliation wicri:level="1"><nlm:aff id="aff39"><addr-line>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Wallon, David" sort="Wallon, David" uniqKey="Wallon D" first="David" last="Wallon">David Wallon</name><affiliation wicri:level="3"><nlm:aff id="aff35"><addr-line>CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name><affiliation wicri:level="1"><nlm:aff id="aff59"><addr-line>University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name><affiliation wicri:level="4"><nlm:aff id="aff60"><addr-line>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><affiliation wicri:level="1"><nlm:aff id="aff61"><addr-line>Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="George Hyslop, Peter St" sort="George Hyslop, Peter St" uniqKey="George Hyslop P" first="Peter St" last="George-Hyslop">Peter St George-Hyslop</name><affiliation wicri:level="4"><nlm:aff id="aff60"><addr-line>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff62"><addr-line>Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name><affiliation wicri:level="4"><nlm:aff id="aff63"><addr-line>Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff64"><addr-line>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lleo, Alberto" sort="Lleo, Alberto" uniqKey="Lleo A" first="Alberto" last="Lleo">Alberto Lleo</name><affiliation wicri:level="4"><nlm:aff id="aff63"><addr-line>Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff64"><addr-line>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bayer, Anthony" sort="Bayer, Anthony" uniqKey="Bayer A" first="Anthony" last="Bayer">Anthony Bayer</name><affiliation wicri:level="1"><nlm:aff id="aff61"><addr-line>Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Tsuang, Debby W" sort="Tsuang, Debby W" uniqKey="Tsuang D" first="Debby W." last="Tsuang">Debby W. Tsuang</name><affiliation wicri:level="4"><nlm:aff id="aff65"><addr-line>Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><affiliation wicri:level="2"><nlm:aff id="aff66"><addr-line>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name><affiliation wicri:level="1"><nlm:aff id="aff67"><addr-line>3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece</addr-line></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Bossu, Paola" sort="Bossu, Paola" uniqKey="Bossu P" first="Paola" last="Bossù">Paola Bossù</name><affiliation wicri:level="3"><nlm:aff id="aff68"><addr-line>Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Spalletta, Gianfranco" sort="Spalletta, Gianfranco" uniqKey="Spalletta G" first="Gianfranco" last="Spalletta">Gianfranco Spalletta</name><affiliation wicri:level="3"><nlm:aff id="aff68"><addr-line>Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Proitsi, Petra" sort="Proitsi, Petra" uniqKey="Proitsi P" first="Petra" last="Proitsi">Petra Proitsi</name><affiliation><nlm:aff id="aff46"><addr-line>King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom</addr-line></nlm:aff><wicri:noCountry code="subfield">United Kingom</wicri:noCountry></affiliation></author><author><name sortKey="Collinge, John" sort="Collinge, John" uniqKey="Collinge J" first="John" last="Collinge">John Collinge</name><affiliation wicri:level="3"><nlm:aff id="aff69"><addr-line>MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><affiliation wicri:level="1"><nlm:aff id="aff70"><addr-line>NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff71"><addr-line>Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Garcia, Florentino Sanchez" sort="Garcia, Florentino Sanchez" uniqKey="Garcia F" first="Florentino Sanchez" last="Garcia">Florentino Sanchez Garcia</name><affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria</wicri:regionArea><wicri:noRegion>Las Palmas de Gran Canaria</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name><affiliation wicri:level="3"><nlm:aff id="aff73"><addr-line>Dementia Research Center, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dementia Research Center, Department of Neurodegenerative Disease, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="3"><nlm:aff id="aff74"><addr-line>Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Naranjo, Maria Candida Deniz" sort="Naranjo, Maria Candida Deniz" uniqKey="Naranjo M" first="Maria Candida Deniz" last="Naranjo">Maria Candida Deniz Naranjo</name><affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria</wicri:regionArea><wicri:noRegion>Las Palmas de Gran Canaria</wicri:noRegion></affiliation></author><author><name sortKey="Bosco, Paolo" sort="Bosco, Paolo" uniqKey="Bosco P" first="Paolo" last="Bosco">Paolo Bosco</name><affiliation wicri:level="1"><nlm:aff id="aff75"><addr-line>IRCCS Associazione Oasi Maria SS, Troina, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Associazione Oasi Maria SS, Troina</wicri:regionArea><wicri:noRegion>Troina</wicri:noRegion></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation wicri:level="4"><nlm:aff id="aff76"><addr-line>Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name><affiliation wicri:level="4"><nlm:aff id="aff77"><addr-line>Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><affiliation wicri:level="3"><nlm:aff id="aff78"><addr-line>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name><affiliation wicri:level="3"><nlm:aff id="aff78"><addr-line>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bonuccelli, Ubaldo" sort="Bonuccelli, Ubaldo" uniqKey="Bonuccelli U" first="Ubaldo" last="Bonuccelli">Ubaldo Bonuccelli</name><affiliation wicri:level="4"><nlm:aff id="aff79"><addr-line>Neurological Clinic, University of Pisa, Pisa, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Neurological Clinic, University of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region><settlement type="city">Pise</settlement></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Mancuso, Michelangelo" sort="Mancuso, Michelangelo" uniqKey="Mancuso M" first="Michelangelo" last="Mancuso">Michelangelo Mancuso</name><affiliation wicri:level="4"><nlm:aff id="aff79"><addr-line>Neurological Clinic, University of Pisa, Pisa, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Neurological Clinic, University of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region><settlement type="city">Pise</settlement></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Siciliano, Gabriele" sort="Siciliano, Gabriele" uniqKey="Siciliano G" first="Gabriele" last="Siciliano">Gabriele Siciliano</name><affiliation wicri:level="4"><nlm:aff id="aff79"><addr-line>Neurological Clinic, University of Pisa, Pisa, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Neurological Clinic, University of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region><settlement type="city">Pise</settlement></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><affiliation wicri:level="1"><nlm:aff id="aff80"><addr-line>Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name><affiliation wicri:level="1"><nlm:aff id="aff81"><addr-line>Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Zompo, Maria Del" sort="Zompo, Maria Del" uniqKey="Zompo M" first="Maria Del" last="Zompo">Maria Del Zompo</name><affiliation wicri:level="1"><nlm:aff id="aff82"><addr-line>Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari</wicri:regionArea><wicri:noRegion>Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name><affiliation wicri:level="3"><nlm:aff id="aff83"><addr-line>Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation><nlm:aff id="aff84"><addr-line>Department of Psychiatry, University of Frankfurt am Main, Frankfurt am Main, Germany (H.H.)</addr-line></nlm:aff><wicri:noCountry code="subfield">Germany (H.H.)</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="aff85"><addr-line>Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Ludwig-Maximilians University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Pilotto, Alberto" sort="Pilotto, Alberto" uniqKey="Pilotto A" first="Alberto" last="Pilotto">Alberto Pilotto</name><affiliation wicri:level="1"><nlm:aff id="aff86"><addr-line>Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG)</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo (FG)</wicri:noRegion></affiliation></author><author><name sortKey="Frank Garcia, Ana" sort="Frank Garcia, Ana" uniqKey="Frank Garcia A" first="Ana" last="Frank-García">Ana Frank-García</name><affiliation wicri:level="1"><nlm:aff id="aff87"><addr-line>Centro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="aff88"><addr-line>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff89"><addr-line>Instituto de Investigación Sanitaria “Hospital la Paz” (IdIPaz), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Investigación Sanitaria “Hospital la Paz” (IdIPaz), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Panza, Francesco" sort="Panza, Francesco" uniqKey="Panza F" first="Francesco" last="Panza">Francesco Panza</name><affiliation wicri:level="1"><nlm:aff id="aff90"><addr-line>Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics,Center for Aging Brain,University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Solfrizzi, Vincenzo" sort="Solfrizzi, Vincenzo" uniqKey="Solfrizzi V" first="Vincenzo" last="Solfrizzi">Vincenzo Solfrizzi</name><affiliation wicri:level="1"><nlm:aff id="aff90"><addr-line>Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics,Center for Aging Brain,University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Caffarra, Paolo" sort="Caffarra, Paolo" uniqKey="Caffarra P" first="Paolo" last="Caffarra">Paolo Caffarra</name><affiliation wicri:level="1"><nlm:aff id="aff91"><addr-line>Department of Neuroscience-University of Parma, Parma, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience-University of Parma, Parma</wicri:regionArea><wicri:noRegion>Parma</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff92"><addr-line>Center for Cognitive Disorders AUSL, Parma, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Cognitive Disorders AUSL, Parma</wicri:regionArea><wicri:noRegion>Parma</wicri:noRegion></affiliation></author><author><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><affiliation wicri:level="1"><nlm:aff id="aff70"><addr-line>NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff71"><addr-line>Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Perry, William" sort="Perry, William" uniqKey="Perry W" first="William" last="Perry">William Perry</name><affiliation wicri:level="2"><nlm:aff id="aff12"><addr-line>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff13"><addr-line>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Mayhaus, Manuel" sort="Mayhaus, Manuel" uniqKey="Mayhaus M" first="Manuel" last="Mayhaus">Manuel Mayhaus</name><affiliation wicri:level="1"><nlm:aff id="aff93"><addr-line>Department Of Psychiatry, University Hospital, Saarland, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department Of Psychiatry, University Hospital, Saarland</wicri:regionArea><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion></affiliation></author><author><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name><affiliation wicri:level="4"><nlm:aff id="aff94"><addr-line>Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health/Geriatrics, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation wicri:level="2"><nlm:aff id="aff95"><addr-line>Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Pichler, Sabrina" sort="Pichler, Sabrina" uniqKey="Pichler S" first="Sabrina" last="Pichler">Sabrina Pichler</name><affiliation wicri:level="1"><nlm:aff id="aff93"><addr-line>Department Of Psychiatry, University Hospital, Saarland, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department Of Psychiatry, University Hospital, Saarland</wicri:regionArea><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion></affiliation></author><author><name sortKey="Carrasquillo, Minerva M" sort="Carrasquillo, Minerva M" uniqKey="Carrasquillo M" first="Minerva M." last="Carrasquillo">Minerva M. Carrasquillo</name><affiliation wicri:level="2"><nlm:aff id="aff96"><addr-line>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Ingelsson, Martin" sort="Ingelsson, Martin" uniqKey="Ingelsson M" first="Martin" last="Ingelsson">Martin Ingelsson</name><affiliation wicri:level="4"><nlm:aff id="aff94"><addr-line>Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health/Geriatrics, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Beekly, Duane" sort="Beekly, Duane" uniqKey="Beekly D" first="Duane" last="Beekly">Duane Beekly</name><affiliation wicri:level="4"><nlm:aff id="aff97"><addr-line>National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name><affiliation wicri:level="1"><nlm:aff id="aff98"><addr-line>Genetica molecular-Huca-Oviedo, Oviedo, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetica molecular-Huca-Oviedo, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Zou, Fanggeng" sort="Zou, Fanggeng" uniqKey="Zou F" first="Fanggeng" last="Zou">Fanggeng Zou</name><affiliation wicri:level="2"><nlm:aff id="aff96"><addr-line>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G." last="Younkin">Steven G. Younkin</name><affiliation wicri:level="2"><nlm:aff id="aff96"><addr-line>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Coto, Eliecer" sort="Coto, Eliecer" uniqKey="Coto E" first="Eliecer" last="Coto">Eliecer Coto</name><affiliation wicri:level="1"><nlm:aff id="aff98"><addr-line>Genetica molecular-Huca-Oviedo, Oviedo, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetica molecular-Huca-Oviedo, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Hamilton Nelson, Kara L" sort="Hamilton Nelson, Kara L" uniqKey="Hamilton Nelson K" first="Kara L." last="Hamilton-Nelson">Kara L. Hamilton-Nelson</name><affiliation wicri:level="2"><nlm:aff id="aff12"><addr-line>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Gu, Wei" sort="Gu, Wei" uniqKey="Gu W" first="Wei" last="Gu">Wei Gu</name><affiliation wicri:level="1"><nlm:aff id="aff99"><addr-line>Department of Psychiatry, University Hospital, Saarland, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, University Hospital, Saarland</wicri:regionArea><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion></affiliation></author><author><name sortKey="Razquin, Cristina" sort="Razquin, Cristina" uniqKey="Razquin C" first="Cristina" last="Razquin">Cristina Razquin</name><affiliation wicri:level="1"><nlm:aff id="aff100"><addr-line>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name><affiliation wicri:level="1"><nlm:aff id="aff100"><addr-line>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff101"><addr-line>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Mateo, Ignacio" sort="Mateo, Ignacio" uniqKey="Mateo I" first="Ignacio" last="Mateo">Ignacio Mateo</name><affiliation wicri:level="1"><nlm:aff id="aff102"><addr-line>Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J." last="Owen">Michael J. Owen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Faber, Kelley M" sort="Faber, Kelley M" uniqKey="Faber K" first="Kelley M." last="Faber">Kelley M. Faber</name><affiliation wicri:level="2"><nlm:aff id="aff103"><addr-line>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V." last="Jonsson">Palmi V. Jonsson</name><affiliation wicri:level="1"><nlm:aff id="aff16"><addr-line>University of Iceland, Faculty of Medicine, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff104"><addr-line>Landspitali University Hospital, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Landspitali University Hospital, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Combarros, Onofre" sort="Combarros, Onofre" uniqKey="Combarros O" first="Onofre" last="Combarros">Onofre Combarros</name><affiliation wicri:level="1"><nlm:aff id="aff102"><addr-line>Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="O Donovan, Michael C" sort="O Donovan, Michael C" uniqKey="O Donovan M" first="Michael C." last="O'Donovan">Michael C. O'Donovan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Cantwell, Laura B" sort="Cantwell, Laura B" uniqKey="Cantwell L" first="Laura B." last="Cantwell">Laura B. Cantwell</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation wicri:level="1"><nlm:aff id="aff105"><addr-line>Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff106"><addr-line>Department of Neurology, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, Kuopio University Hospital, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Blacker, Deborah" sort="Blacker, Deborah" uniqKey="Blacker D" first="Deborah" last="Blacker">Deborah Blacker</name><affiliation wicri:level="2"><nlm:aff id="aff107"><addr-line>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff108"><addr-line>Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name><affiliation wicri:level="3"><nlm:aff id="aff69"><addr-line>MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name><affiliation wicri:level="2"><nlm:aff id="aff109"><addr-line>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi</wicri:regionArea><placeName><region type="state">État du Mississippi</region></placeName></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name><affiliation wicri:level="2"><nlm:aff id="aff66"><addr-line>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff110"><addr-line>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation wicri:level="2"><nlm:aff id="aff111"><addr-line>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Fratiglioni, Laura" sort="Fratiglioni, Laura" uniqKey="Fratiglioni L" first="Laura" last="Fratiglioni">Laura Fratiglioni</name><affiliation wicri:level="3"><nlm:aff id="aff112"><addr-line>Aging Research Center, Department Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Aging Research Center, Department Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff113"><addr-line>Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name><affiliation wicri:level="1"><nlm:aff id="aff114"><addr-line>Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renee F. A. G." last="De Bruijn">Renee F. A. G. De Bruijn</name><affiliation wicri:level="3"><nlm:aff id="aff115"><addr-line>Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Passmore, Peter" sort="Passmore, Peter" uniqKey="Passmore P" first="Peter" last="Passmore">Peter Passmore</name><affiliation wicri:level="1"><nlm:aff id="aff39"><addr-line>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name><affiliation wicri:level="4"><nlm:aff id="aff116"><addr-line>Department of Pathology, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><affiliation wicri:level="1"><nlm:aff id="aff49"><addr-line>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff50"><addr-line>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation wicri:level="2"><nlm:aff id="aff117"><addr-line>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="4"><nlm:aff id="aff118"><addr-line>INSERM UMR_S975-CNRS UMR 7225, Université Pierre et Marie Curie, Centre de recherche de l'Institut du Cerveau et de la Moëlle épinière-CRICM, Hôpital de la Salpêtrière, Paris France</addr-line></nlm:aff><orgName type="university">Université Pierre-et-Marie-Curie</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff119"><addr-line>AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital de la Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name><affiliation wicri:level="4"><nlm:aff id="aff53"><addr-line>Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M." last="Foroud">Tatiana M. Foroud</name><affiliation wicri:level="2"><nlm:aff id="aff103"><addr-line>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A." last="Kukull">Walter A. Kukull</name><affiliation wicri:level="4"><nlm:aff id="aff120"><addr-line>Department of Epidemiology, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation wicri:level="3"><nlm:aff id="aff35"><addr-line>CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F." last="Powell">John F. Powell</name><affiliation><nlm:aff id="aff46"><addr-line>King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom</addr-line></nlm:aff><wicri:noCountry code="subfield">United Kingom</wicri:noCountry></affiliation></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name><affiliation wicri:level="2"><nlm:aff id="aff121"><addr-line>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation wicri:level="3"><nlm:aff id="aff41"><addr-line>INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff122"><addr-line>Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L." last="Lunetta">Kathryn L. Lunetta</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kauwe, John S K" sort="Kauwe, John S K" uniqKey="Kauwe J" first="John S. K." last="Kauwe">John S. K. Kauwe</name><affiliation wicri:level="2"><nlm:aff id="aff123"><addr-line>Department of Biology, Brigham Young University, Provo, Utah, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, Brigham Young University, Provo, Utah</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation wicri:level="2"><nlm:aff id="aff124"><addr-line>Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff125"><addr-line>Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Riemenschneider, Matthias" sort="Riemenschneider, Matthias" uniqKey="Riemenschneider M" first="Matthias" last="Riemenschneider">Matthias Riemenschneider</name><affiliation wicri:level="1"><nlm:aff id="aff99"><addr-line>Department of Psychiatry, University Hospital, Saarland, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, University Hospital, Saarland</wicri:regionArea><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion></affiliation></author><author><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff126"><addr-line>Hospital Universitari Vall d'Hebron - Institut de Recerca, Universitat Autònoma de Barcelona. (VHIR-UAB), Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitari Vall d'Hebron - Institut de Recerca, Universitat Autònoma de Barcelona. (VHIR-UAB), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name><affiliation wicri:level="1"><nlm:aff id="aff105"><addr-line>Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff106"><addr-line>Department of Neurology, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, Kuopio University Hospital, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R." last="Martin">Eden R. Martin</name><affiliation wicri:level="2"><nlm:aff id="aff12"><addr-line>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff13"><addr-line>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="aff127"><addr-line>Department of Neurology, Medical University Graz, Graz, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name><affiliation wicri:level="4"><nlm:aff id="aff85"><addr-line>Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Ludwig-Maximilians University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation wicri:level="3"><nlm:aff id="aff47"><addr-line>Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff128"><addr-line>Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name><affiliation wicri:level="2"><nlm:aff id="aff27"><addr-line>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff28"><addr-line>Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="3"><nlm:aff id="aff129"><addr-line>Inserm U708, Victor Segalen University, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U708, Victor Segalen University, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff20"><addr-line>Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name><affiliation wicri:level="3"><nlm:aff id="aff130"><addr-line>Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Graff, Caroline" sort="Graff, Caroline" uniqKey="Graff C" first="Caroline" last="Graff">Caroline Graff</name><affiliation wicri:level="3"><nlm:aff id="aff113"><addr-line>Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff131"><addr-line>Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KIADRC, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KIADRC, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation wicri:level="4"><nlm:aff id="aff11"><addr-line>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff132"><addr-line>Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Group Health Cooperative, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name><affiliation wicri:level="2"><nlm:aff id="aff133"><addr-line>Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff134"><addr-line>Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff22"><addr-line>Fondation Jean Dausset- CEPH, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Jean Dausset- CEPH, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff135"><addr-line>McGill University and Génome Québec Innovation Centre, Montreal, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>McGill University and Génome Québec Innovation Centre, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name><affiliation wicri:level="2"><nlm:aff id="aff12"><addr-line>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff13"><addr-line>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation wicri:level="2"><nlm:aff id="aff111"><addr-line>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation wicri:level="1"><nlm:aff id="aff49"><addr-line>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff50"><addr-line>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff9"><addr-line>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff136"><addr-line>Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff137"><addr-line>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="3"><nlm:aff id="aff20"><addr-line>Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff40"><addr-line>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff138"><addr-line>Center for Medical Systems Biology, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Center for Medical Systems Biology, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ramirez, Alfredo" sort="Ramirez, Alfredo" uniqKey="Ramirez A" first="Alfredo" last="Ramirez">Alfredo Ramirez</name><affiliation wicri:level="3"><nlm:aff id="aff139"><addr-line>Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><nlm:aff id="aff18"><addr-line>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff140"><addr-line>The Framingham Heart Study, Framingham, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Framingham Heart Study, Framingham, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D." last="Schellenberg">Gerard D. Schellenberg</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Inserm U744, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Université Lille 2, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff29"><addr-line>CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff141"><addr-line>Centre Hospitalier Régional Universitaire de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24922517</idno><idno type="pmc">4055488</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055488</idno><idno type="RBID">PMC:4055488</idno><idno type="doi">10.1371/journal.pone.0094661</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001D58</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D58</idno><idno type="wicri:Area/Pmc/Curation">001D33</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001D33</idno><idno type="wicri:Area/Pmc/Checkpoint">001241</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001241</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002871</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002871</idno><idno type="wicri:Area/PubMed/Curation">002858</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002858</idno><idno type="wicri:Area/PubMed/Checkpoint">002858</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002858</idno><idno type="wicri:Area/Ncbi/Merge">002490</idno><idno type="wicri:Area/Ncbi/Curation">002490</idno><idno type="wicri:Area/Ncbi/Checkpoint">002490</idno><idno type="wicri:Area/Main/Merge">002D78</idno><idno type="wicri:Area/Main/Curation">002C49</idno><idno type="wicri:Area/Main/Exploration">002C49</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease</title><author><name sortKey="Escott Price, Valentina" sort="Escott Price, Valentina" uniqKey="Escott Price V" first="Valentina" last="Escott-Price">Valentina Escott-Price</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Inserm U744, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Université Lille 2, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Wang, Li San" sort="Wang, Li San" uniqKey="Wang L" first="Li-San" last="Wang">Li-San Wang</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Harold, Denise" sort="Harold, Denise" uniqKey="Harold D" first="Denise" last="Harold">Denise Harold</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Lesley" sort="Jones, Lesley" uniqKey="Jones L" first="Lesley" last="Jones">Lesley Jones</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Holmans, Peter" sort="Holmans, Peter" uniqKey="Holmans P" first="Peter" last="Holmans">Peter Holmans</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Gerrish, Amy" sort="Gerrish, Amy" uniqKey="Gerrish A" first="Amy" last="Gerrish">Amy Gerrish</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Vedernikov, Alexey" sort="Vedernikov, Alexey" uniqKey="Vedernikov A" first="Alexey" last="Vedernikov">Alexey Vedernikov</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Richards, Alexander" sort="Richards, Alexander" uniqKey="Richards A" first="Alexander" last="Richards">Alexander Richards</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Inserm U744, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Université Lille 2, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name><affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>Department of Epidemiology and Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology and Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Naj, Adam C" sort="Naj, Adam C" uniqKey="Naj A" first="Adam C." last="Naj">Adam C. Naj</name><affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Sims, Rebecca" sort="Sims, Rebecca" uniqKey="Sims R" first="Rebecca" last="Sims">Rebecca Sims</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff9"><addr-line>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation wicri:level="4"><nlm:aff id="aff11"><addr-line>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W." last="Beecham">Gary W. Beecham</name><affiliation wicri:level="2"><nlm:aff id="aff12"><addr-line>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff13"><addr-line>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Inserm U744, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Université Lille 2, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Russo, Giancarlo" sort="Russo, Giancarlo" uniqKey="Russo G" first="Giancarlo" last="Russo">Giancarlo Russo</name><affiliation wicri:level="4"><nlm:aff id="aff14"><addr-line>Functional Genomics Center Zurich, ETH/University of Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Functional Genomics Center Zurich, ETH/University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Thornton Wells, Tricia A" sort="Thornton Wells, Tricia A" uniqKey="Thornton Wells T" first="Tricia A." last="Thornton-Wells">Tricia A. Thornton-Wells</name><affiliation wicri:level="2"><nlm:aff id="aff15"><addr-line>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Denning, Nicola" sort="Denning, Nicola" uniqKey="Denning N" first="Nicola" last="Denning">Nicola Denning</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:aff id="aff16"><addr-line>University of Iceland, Faculty of Medicine, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Icelandic Heart Association, Kopavogur, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Inserm U744, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Université Lille 2, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff18"><addr-line>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Thomas, Charlene" sort="Thomas, Charlene" uniqKey="Thomas C" first="Charlene" last="Thomas">Charlene Thomas</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name><affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff20"><addr-line>Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name><affiliation wicri:level="3"><nlm:aff id="aff21"><addr-line>Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N." last="Vardarajan">Badri N. Vardarajan</name><affiliation wicri:level="2"><nlm:aff id="aff9"><addr-line>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff27"><addr-line>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff28"><addr-line>Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Kamatani, Yoichiro" sort="Kamatani, Yoichiro" uniqKey="Kamatani Y" first="Yoichiro" last="Kamatani">Yoichiro Kamatani</name><affiliation wicri:level="3"><nlm:aff id="aff22"><addr-line>Fondation Jean Dausset- CEPH, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Jean Dausset- CEPH, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lin, Chiao Feng" sort="Lin, Chiao Feng" uniqKey="Lin C" first="Chiao-Feng" last="Lin">Chiao-Feng Lin</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="aff23"><addr-line>Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Kunkle, Brian" sort="Kunkle, Brian" uniqKey="Kunkle B" first="Brian" last="Kunkle">Brian Kunkle</name><affiliation wicri:level="2"><nlm:aff id="aff12"><addr-line>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Dunstan, Melanie L" sort="Dunstan, Melanie L" uniqKey="Dunstan M" first="Melanie L." last="Dunstan">Melanie L. Dunstan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Vronskaya, Maria" sort="Vronskaya, Maria" uniqKey="Vronskaya M" first="Maria" last="Vronskaya">Maria Vronskaya</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name><affiliation wicri:level="2"><nlm:aff id="aff25"><addr-line>NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ruiz, Agustin" sort="Ruiz, Agustin" uniqKey="Ruiz A" first="Agustin" last="Ruiz">Agustin Ruiz</name><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bihoreau, Marie Therese" sort="Bihoreau, Marie Therese" uniqKey="Bihoreau M" first="Marie-Thérèse" last="Bihoreau">Marie-Thérèse Bihoreau</name><affiliation wicri:level="3"><nlm:aff id="aff21"><addr-line>Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de Genotypage, Institut Genomique, Commissariat à l'énergie Atomique, Evry</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Reitz, Christiane" sort="Reitz, Christiane" uniqKey="Reitz C" first="Christiane" last="Reitz">Christiane Reitz</name><affiliation wicri:level="2"><nlm:aff id="aff27"><addr-line>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff28"><addr-line>Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Université Lille 2, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff29"><addr-line>CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Hollingworth, Paul" sort="Hollingworth, Paul" uniqKey="Hollingworth P" first="Paul" last="Hollingworth">Paul Hollingworth</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Hanon, Olivier" sort="Hanon, Olivier" uniqKey="Hanon O" first="Olivier" last="Hanon">Olivier Hanon</name><affiliation wicri:level="3"><nlm:aff id="aff30"><addr-line>University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics department, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Sorbonne Paris V, Broca Hospital, Geriatrics department, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L." last="Fitzpatrick">Annette L. Fitzpatrick</name><affiliation wicri:level="4"><nlm:aff id="aff11"><addr-line>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff31"><addr-line>Departments of Epidemiology and Global Health, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Epidemiology and Global Health, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name><affiliation wicri:level="2"><nlm:aff id="aff32"><addr-line>Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mount Sinai School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff33"><addr-line>Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Mount Sinai School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff34"><addr-line>Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><affiliation wicri:level="3"><nlm:aff id="aff35"><addr-line>CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Crane, Paul K" sort="Crane, Paul K" uniqKey="Crane P" first="Paul K." last="Crane">Paul K. Crane</name><affiliation wicri:level="4"><nlm:aff id="aff36"><addr-line>Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Baldwin, Clinton" sort="Baldwin, Clinton" uniqKey="Baldwin C" first="Clinton" last="Baldwin">Clinton Baldwin</name><affiliation wicri:level="2"><nlm:aff id="aff9"><addr-line>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name><affiliation wicri:level="3"><nlm:aff id="aff37"><addr-line>German Center for Neurodegenerative Diseases (DZNE), Bonn, and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn, and Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="aff16"><addr-line>University of Iceland, Faculty of Medicine, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Icelandic Heart Association, Kopavogur, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name><affiliation wicri:level="4"><nlm:aff id="aff38"><addr-line>Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Craig, David" sort="Craig, David" uniqKey="Craig D" first="David" last="Craig">David Craig</name><affiliation wicri:level="1"><nlm:aff id="aff39"><addr-line>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="3"><nlm:aff id="aff40"><addr-line>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation wicri:level="3"><nlm:aff id="aff41"><addr-line>INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name><affiliation wicri:level="2"><nlm:aff id="aff42"><addr-line>Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L." last="De Jager">Philip L. De Jager</name><affiliation wicri:level="2"><nlm:aff id="aff43"><addr-line>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff44"><addr-line>Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Université Lille 2, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff29"><addr-line>CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Johnston, Janet A" sort="Johnston, Janet A" uniqKey="Johnston J" first="Janet A." last="Johnston">Janet A. Johnston</name><affiliation wicri:level="1"><nlm:aff id="aff39"><addr-line>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name><affiliation wicri:level="2"><nlm:aff id="aff45"><addr-line>Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><affiliation><nlm:aff id="aff46"><addr-line>King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom</addr-line></nlm:aff><wicri:noCountry code="subfield">United Kingom</wicri:noCountry></affiliation></author><author><name sortKey="Letenneur, Luc" sort="Letenneur, Luc" uniqKey="Letenneur L" first="Luc" last="Letenneur">Luc Letenneur</name><affiliation wicri:level="1"><nlm:aff id="aff47"><addr-line>Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><wicri:noRegion>33076, Bordeaux</wicri:noRegion><wicri:noRegion>33076, Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Hernandez, Isabel" sort="Hernandez, Isabel" uniqKey="Hernandez I" first="Isabel" last="Hernández">Isabel Hernández</name><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rubinsztein, David C" sort="Rubinsztein, David C" uniqKey="Rubinsztein D" first="David C." last="Rubinsztein">David C. Rubinsztein</name><affiliation wicri:level="4"><nlm:aff id="aff48"><addr-line>Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Institute for Medical Research, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation wicri:level="1"><nlm:aff id="aff17"><addr-line>Icelandic Heart Association, Kopavogur, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea><wicri:noRegion>Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name><affiliation wicri:level="1"><nlm:aff id="aff49"><addr-line>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff50"><addr-line>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Goate, Alison M" sort="Goate, Alison M" uniqKey="Goate A" first="Alison M." last="Goate">Alison M. Goate</name><affiliation wicri:level="4"><nlm:aff id="aff38"><addr-line>Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Inserm U744, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Huentelman, Matthew J" sort="Huentelman, Matthew J" uniqKey="Huentelman M" first="Matthew J." last="Huentelman">Matthew J. Huentelman</name><affiliation wicri:level="2"><nlm:aff id="aff51"><addr-line>Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name><affiliation wicri:level="1"><nlm:aff id="aff52"><addr-line>Discipline of Psychiatry, Trinity College, Dublin, Ireland</addr-line></nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Discipline of Psychiatry, Trinity College, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Brown, Kristelle" sort="Brown, Kristelle" uniqKey="Brown K" first="Kristelle" last="Brown">Kristelle Brown</name><affiliation wicri:level="4"><nlm:aff id="aff53"><addr-line>Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name><affiliation wicri:level="4"><nlm:aff id="aff54"><addr-line>Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff55"><addr-line>Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Keller, Lina" sort="Keller, Lina" uniqKey="Keller L" first="Lina" last="Keller">Lina Keller</name><affiliation wicri:level="3"><nlm:aff id="aff56"><addr-line>Aging Reasearch Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Aging Reasearch Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Barberger Gateau, Pascale" sort="Barberger Gateau, Pascale" uniqKey="Barberger Gateau P" first="Pascale" last="Barberger-Gateau">Pascale Barberger-Gateau</name><affiliation><nlm:aff id="aff46"><addr-line>King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom</addr-line></nlm:aff><wicri:noCountry code="subfield">United Kingom</wicri:noCountry></affiliation></author><author><name sortKey="Mcguinness, Bernadette" sort="Mcguinness, Bernadette" uniqKey="Mcguinness B" first="Bernadette" last="Mcguinness">Bernadette Mcguinness</name><affiliation wicri:level="1"><nlm:aff id="aff39"><addr-line>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B." last="Larson">Eric B. Larson</name><affiliation wicri:level="4"><nlm:aff id="aff36"><addr-line>Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff57"><addr-line>Group Health Research Institute, Group Health, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Group Health, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Myers, Amanda J" sort="Myers, Amanda J" uniqKey="Myers A" first="Amanda J." last="Myers">Amanda J. Myers</name><affiliation wicri:level="2"><nlm:aff id="aff58"><addr-line>Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><affiliation wicri:level="3"><nlm:aff id="aff47"><addr-line>Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Todd, Stephen" sort="Todd, Stephen" uniqKey="Todd S" first="Stephen" last="Todd">Stephen Todd</name><affiliation wicri:level="1"><nlm:aff id="aff39"><addr-line>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Wallon, David" sort="Wallon, David" uniqKey="Wallon D" first="David" last="Wallon">David Wallon</name><affiliation wicri:level="3"><nlm:aff id="aff35"><addr-line>CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name><affiliation wicri:level="1"><nlm:aff id="aff59"><addr-line>University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol</wicri:regionArea><wicri:noRegion>Bristol</wicri:noRegion></affiliation></author><author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name><affiliation wicri:level="4"><nlm:aff id="aff60"><addr-line>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><affiliation wicri:level="1"><nlm:aff id="aff61"><addr-line>Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="George Hyslop, Peter St" sort="George Hyslop, Peter St" uniqKey="George Hyslop P" first="Peter St" last="George-Hyslop">Peter St George-Hyslop</name><affiliation wicri:level="4"><nlm:aff id="aff60"><addr-line>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff62"><addr-line>Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Clarimon, Jordi" sort="Clarimon, Jordi" uniqKey="Clarimon J" first="Jordi" last="Clarimon">Jordi Clarimon</name><affiliation wicri:level="4"><nlm:aff id="aff63"><addr-line>Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff64"><addr-line>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lleo, Alberto" sort="Lleo, Alberto" uniqKey="Lleo A" first="Alberto" last="Lleo">Alberto Lleo</name><affiliation wicri:level="4"><nlm:aff id="aff63"><addr-line>Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Department. IIB Sant Pau. Sant Pau Hospital. Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region><settlement type="city">Barcelone</settlement></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff64"><addr-line>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Networker Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bayer, Anthony" sort="Bayer, Anthony" uniqKey="Bayer A" first="Anthony" last="Bayer">Anthony Bayer</name><affiliation wicri:level="1"><nlm:aff id="aff61"><addr-line>Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Primary Care and Public Health, Cardiff University, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Tsuang, Debby W" sort="Tsuang, Debby W" uniqKey="Tsuang D" first="Debby W." last="Tsuang">Debby W. Tsuang</name><affiliation wicri:level="4"><nlm:aff id="aff65"><addr-line>Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><affiliation wicri:level="2"><nlm:aff id="aff66"><addr-line>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name><affiliation wicri:level="1"><nlm:aff id="aff67"><addr-line>3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece</addr-line></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Bossu, Paola" sort="Bossu, Paola" uniqKey="Bossu P" first="Paola" last="Bossù">Paola Bossù</name><affiliation wicri:level="3"><nlm:aff id="aff68"><addr-line>Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Spalletta, Gianfranco" sort="Spalletta, Gianfranco" uniqKey="Spalletta G" first="Gianfranco" last="Spalletta">Gianfranco Spalletta</name><affiliation wicri:level="3"><nlm:aff id="aff68"><addr-line>Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical and Behavioral Neurology, Fondazione Santa Lucia, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Proitsi, Petra" sort="Proitsi, Petra" uniqKey="Proitsi P" first="Petra" last="Proitsi">Petra Proitsi</name><affiliation><nlm:aff id="aff46"><addr-line>King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom</addr-line></nlm:aff><wicri:noCountry code="subfield">United Kingom</wicri:noCountry></affiliation></author><author><name sortKey="Collinge, John" sort="Collinge, John" uniqKey="Collinge J" first="John" last="Collinge">John Collinge</name><affiliation wicri:level="3"><nlm:aff id="aff69"><addr-line>MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><affiliation wicri:level="1"><nlm:aff id="aff70"><addr-line>NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff71"><addr-line>Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Garcia, Florentino Sanchez" sort="Garcia, Florentino Sanchez" uniqKey="Garcia F" first="Florentino Sanchez" last="Garcia">Florentino Sanchez Garcia</name><affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria</wicri:regionArea><wicri:noRegion>Las Palmas de Gran Canaria</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name><affiliation wicri:level="3"><nlm:aff id="aff73"><addr-line>Dementia Research Center, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dementia Research Center, Department of Neurodegenerative Disease, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation wicri:level="3"><nlm:aff id="aff74"><addr-line>Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neuroscience and Reta Lilla Weston Laboratories, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Naranjo, Maria Candida Deniz" sort="Naranjo, Maria Candida Deniz" uniqKey="Naranjo M" first="Maria Candida Deniz" last="Naranjo">Maria Candida Deniz Naranjo</name><affiliation wicri:level="1"><nlm:aff id="aff72"><addr-line>Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria</wicri:regionArea><wicri:noRegion>Las Palmas de Gran Canaria</wicri:noRegion></affiliation></author><author><name sortKey="Bosco, Paolo" sort="Bosco, Paolo" uniqKey="Bosco P" first="Paolo" last="Bosco">Paolo Bosco</name><affiliation wicri:level="1"><nlm:aff id="aff75"><addr-line>IRCCS Associazione Oasi Maria SS, Troina, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Associazione Oasi Maria SS, Troina</wicri:regionArea><wicri:noRegion>Troina</wicri:noRegion></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation wicri:level="4"><nlm:aff id="aff76"><addr-line>Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name><affiliation wicri:level="4"><nlm:aff id="aff77"><addr-line>Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cognitive Function and Ageing Study (CFAS), Institute of Public Health, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><affiliation wicri:level="3"><nlm:aff id="aff78"><addr-line>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name><affiliation wicri:level="3"><nlm:aff id="aff78"><addr-line>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Bonuccelli, Ubaldo" sort="Bonuccelli, Ubaldo" uniqKey="Bonuccelli U" first="Ubaldo" last="Bonuccelli">Ubaldo Bonuccelli</name><affiliation wicri:level="4"><nlm:aff id="aff79"><addr-line>Neurological Clinic, University of Pisa, Pisa, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Neurological Clinic, University of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region><settlement type="city">Pise</settlement></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Mancuso, Michelangelo" sort="Mancuso, Michelangelo" uniqKey="Mancuso M" first="Michelangelo" last="Mancuso">Michelangelo Mancuso</name><affiliation wicri:level="4"><nlm:aff id="aff79"><addr-line>Neurological Clinic, University of Pisa, Pisa, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Neurological Clinic, University of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region><settlement type="city">Pise</settlement></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Siciliano, Gabriele" sort="Siciliano, Gabriele" uniqKey="Siciliano G" first="Gabriele" last="Siciliano">Gabriele Siciliano</name><affiliation wicri:level="4"><nlm:aff id="aff79"><addr-line>Neurological Clinic, University of Pisa, Pisa, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Neurological Clinic, University of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region><settlement type="city">Pise</settlement></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><affiliation wicri:level="1"><nlm:aff id="aff80"><addr-line>Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Urban Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name><affiliation wicri:level="1"><nlm:aff id="aff81"><addr-line>Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Zompo, Maria Del" sort="Zompo, Maria Del" uniqKey="Zompo M" first="Maria Del" last="Zompo">Maria Del Zompo</name><affiliation wicri:level="1"><nlm:aff id="aff82"><addr-line>Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari</wicri:regionArea><wicri:noRegion>Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name><affiliation wicri:level="3"><nlm:aff id="aff83"><addr-line>Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Bonn, Germany and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Hampel, Harald" sort="Hampel, Harald" uniqKey="Hampel H" first="Harald" last="Hampel">Harald Hampel</name><affiliation><nlm:aff id="aff84"><addr-line>Department of Psychiatry, University of Frankfurt am Main, Frankfurt am Main, Germany (H.H.)</addr-line></nlm:aff><wicri:noCountry code="subfield">Germany (H.H.)</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="aff85"><addr-line>Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Ludwig-Maximilians University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Pilotto, Alberto" sort="Pilotto, Alberto" uniqKey="Pilotto A" first="Alberto" last="Pilotto">Alberto Pilotto</name><affiliation wicri:level="1"><nlm:aff id="aff86"><addr-line>Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Gerontology and Geriatrics Research Laboratory, I.R.C.C.S. Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG)</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo (FG)</wicri:noRegion></affiliation></author><author><name sortKey="Frank Garcia, Ana" sort="Frank Garcia, Ana" uniqKey="Frank Garcia A" first="Ana" last="Frank-García">Ana Frank-García</name><affiliation wicri:level="1"><nlm:aff id="aff87"><addr-line>Centro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Biología Molecular Severo Ochoa (CSIC-UAM); Madrid</wicri:regionArea></affiliation><affiliation wicri:level="3"><nlm:aff id="aff88"><addr-line>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff89"><addr-line>Instituto de Investigación Sanitaria “Hospital la Paz” (IdIPaz), Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Investigación Sanitaria “Hospital la Paz” (IdIPaz), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Panza, Francesco" sort="Panza, Francesco" uniqKey="Panza F" first="Francesco" last="Panza">Francesco Panza</name><affiliation wicri:level="1"><nlm:aff id="aff90"><addr-line>Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics,Center for Aging Brain,University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Solfrizzi, Vincenzo" sort="Solfrizzi, Vincenzo" uniqKey="Solfrizzi V" first="Vincenzo" last="Solfrizzi">Vincenzo Solfrizzi</name><affiliation wicri:level="1"><nlm:aff id="aff90"><addr-line>Department of Geriatrics,Center for Aging Brain,University of Bari, Bari, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Geriatrics,Center for Aging Brain,University of Bari, Bari</wicri:regionArea><wicri:noRegion>Bari</wicri:noRegion></affiliation></author><author><name sortKey="Caffarra, Paolo" sort="Caffarra, Paolo" uniqKey="Caffarra P" first="Paolo" last="Caffarra">Paolo Caffarra</name><affiliation wicri:level="1"><nlm:aff id="aff91"><addr-line>Department of Neuroscience-University of Parma, Parma, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroscience-University of Parma, Parma</wicri:regionArea><wicri:noRegion>Parma</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff92"><addr-line>Center for Cognitive Disorders AUSL, Parma, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Cognitive Disorders AUSL, Parma</wicri:regionArea><wicri:noRegion>Parma</wicri:noRegion></affiliation></author><author><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><affiliation wicri:level="1"><nlm:aff id="aff70"><addr-line>NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>NEUROFARBA Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff71"><addr-line>Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Perry, William" sort="Perry, William" uniqKey="Perry W" first="William" last="Perry">William Perry</name><affiliation wicri:level="2"><nlm:aff id="aff12"><addr-line>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff13"><addr-line>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Mayhaus, Manuel" sort="Mayhaus, Manuel" uniqKey="Mayhaus M" first="Manuel" last="Mayhaus">Manuel Mayhaus</name><affiliation wicri:level="1"><nlm:aff id="aff93"><addr-line>Department Of Psychiatry, University Hospital, Saarland, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department Of Psychiatry, University Hospital, Saarland</wicri:regionArea><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion></affiliation></author><author><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name><affiliation wicri:level="4"><nlm:aff id="aff94"><addr-line>Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health/Geriatrics, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation wicri:level="2"><nlm:aff id="aff95"><addr-line>Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Pichler, Sabrina" sort="Pichler, Sabrina" uniqKey="Pichler S" first="Sabrina" last="Pichler">Sabrina Pichler</name><affiliation wicri:level="1"><nlm:aff id="aff93"><addr-line>Department Of Psychiatry, University Hospital, Saarland, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department Of Psychiatry, University Hospital, Saarland</wicri:regionArea><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion></affiliation></author><author><name sortKey="Carrasquillo, Minerva M" sort="Carrasquillo, Minerva M" uniqKey="Carrasquillo M" first="Minerva M." last="Carrasquillo">Minerva M. Carrasquillo</name><affiliation wicri:level="2"><nlm:aff id="aff96"><addr-line>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Ingelsson, Martin" sort="Ingelsson, Martin" uniqKey="Ingelsson M" first="Martin" last="Ingelsson">Martin Ingelsson</name><affiliation wicri:level="4"><nlm:aff id="aff94"><addr-line>Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health/Geriatrics, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Beekly, Duane" sort="Beekly, Duane" uniqKey="Beekly D" first="Duane" last="Beekly">Duane Beekly</name><affiliation wicri:level="4"><nlm:aff id="aff97"><addr-line>National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name><affiliation wicri:level="1"><nlm:aff id="aff98"><addr-line>Genetica molecular-Huca-Oviedo, Oviedo, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetica molecular-Huca-Oviedo, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Zou, Fanggeng" sort="Zou, Fanggeng" uniqKey="Zou F" first="Fanggeng" last="Zou">Fanggeng Zou</name><affiliation wicri:level="2"><nlm:aff id="aff96"><addr-line>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G." last="Younkin">Steven G. Younkin</name><affiliation wicri:level="2"><nlm:aff id="aff96"><addr-line>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Coto, Eliecer" sort="Coto, Eliecer" uniqKey="Coto E" first="Eliecer" last="Coto">Eliecer Coto</name><affiliation wicri:level="1"><nlm:aff id="aff98"><addr-line>Genetica molecular-Huca-Oviedo, Oviedo, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Genetica molecular-Huca-Oviedo, Oviedo</wicri:regionArea><wicri:noRegion>Oviedo</wicri:noRegion></affiliation></author><author><name sortKey="Hamilton Nelson, Kara L" sort="Hamilton Nelson, Kara L" uniqKey="Hamilton Nelson K" first="Kara L." last="Hamilton-Nelson">Kara L. Hamilton-Nelson</name><affiliation wicri:level="2"><nlm:aff id="aff12"><addr-line>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Gu, Wei" sort="Gu, Wei" uniqKey="Gu W" first="Wei" last="Gu">Wei Gu</name><affiliation wicri:level="1"><nlm:aff id="aff99"><addr-line>Department of Psychiatry, University Hospital, Saarland, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, University Hospital, Saarland</wicri:regionArea><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion></affiliation></author><author><name sortKey="Razquin, Cristina" sort="Razquin, Cristina" uniqKey="Razquin C" first="Cristina" last="Razquin">Cristina Razquin</name><affiliation wicri:level="1"><nlm:aff id="aff100"><addr-line>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Pastor, Pau" sort="Pastor, Pau" uniqKey="Pastor P" first="Pau" last="Pastor">Pau Pastor</name><affiliation wicri:level="1"><nlm:aff id="aff100"><addr-line>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff101"><addr-line>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Mateo, Ignacio" sort="Mateo, Ignacio" uniqKey="Mateo I" first="Ignacio" last="Mateo">Ignacio Mateo</name><affiliation wicri:level="1"><nlm:aff id="aff102"><addr-line>Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J." last="Owen">Michael J. Owen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Faber, Kelley M" sort="Faber, Kelley M" uniqKey="Faber K" first="Kelley M." last="Faber">Kelley M. Faber</name><affiliation wicri:level="2"><nlm:aff id="aff103"><addr-line>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V." last="Jonsson">Palmi V. Jonsson</name><affiliation wicri:level="1"><nlm:aff id="aff16"><addr-line>University of Iceland, Faculty of Medicine, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff104"><addr-line>Landspitali University Hospital, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Landspitali University Hospital, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Combarros, Onofre" sort="Combarros, Onofre" uniqKey="Combarros O" first="Onofre" last="Combarros">Onofre Combarros</name><affiliation wicri:level="1"><nlm:aff id="aff102"><addr-line>Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Service and CIBERNED, "Marqués de Valdecilla" University Hospital (University of Cantabria and IFIMAV), Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="O Donovan, Michael C" sort="O Donovan, Michael C" uniqKey="O Donovan M" first="Michael C." last="O'Donovan">Michael C. O'Donovan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Cantwell, Laura B" sort="Cantwell, Laura B" uniqKey="Cantwell L" first="Laura B." last="Cantwell">Laura B. Cantwell</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name><affiliation wicri:level="1"><nlm:aff id="aff105"><addr-line>Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff106"><addr-line>Department of Neurology, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, Kuopio University Hospital, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Blacker, Deborah" sort="Blacker, Deborah" uniqKey="Blacker D" first="Deborah" last="Blacker">Deborah Blacker</name><affiliation wicri:level="2"><nlm:aff id="aff107"><addr-line>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff108"><addr-line>Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name><affiliation wicri:level="3"><nlm:aff id="aff69"><addr-line>MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name><affiliation wicri:level="2"><nlm:aff id="aff109"><addr-line>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi</wicri:regionArea><placeName><region type="state">État du Mississippi</region></placeName></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name><affiliation wicri:level="2"><nlm:aff id="aff66"><addr-line>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff110"><addr-line>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation wicri:level="2"><nlm:aff id="aff111"><addr-line>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Fratiglioni, Laura" sort="Fratiglioni, Laura" uniqKey="Fratiglioni L" first="Laura" last="Fratiglioni">Laura Fratiglioni</name><affiliation wicri:level="3"><nlm:aff id="aff112"><addr-line>Aging Research Center, Department Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Aging Research Center, Department Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff113"><addr-line>Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name><affiliation wicri:level="1"><nlm:aff id="aff114"><addr-line>Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renee F. A. G." last="De Bruijn">Renee F. A. G. De Bruijn</name><affiliation wicri:level="3"><nlm:aff id="aff115"><addr-line>Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Neurology and Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Passmore, Peter" sort="Passmore, Peter" uniqKey="Passmore P" first="Peter" last="Passmore">Peter Passmore</name><affiliation wicri:level="1"><nlm:aff id="aff39"><addr-line>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name><affiliation wicri:level="4"><nlm:aff id="aff116"><addr-line>Department of Pathology, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><affiliation wicri:level="1"><nlm:aff id="aff49"><addr-line>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff50"><addr-line>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation wicri:level="2"><nlm:aff id="aff117"><addr-line>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="4"><nlm:aff id="aff118"><addr-line>INSERM UMR_S975-CNRS UMR 7225, Université Pierre et Marie Curie, Centre de recherche de l'Institut du Cerveau et de la Moëlle épinière-CRICM, Hôpital de la Salpêtrière, Paris France</addr-line></nlm:aff><orgName type="university">Université Pierre-et-Marie-Curie</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff119"><addr-line>AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hôpital de la Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name><affiliation wicri:level="4"><nlm:aff id="aff53"><addr-line>Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author><author><name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M." last="Foroud">Tatiana M. Foroud</name><affiliation wicri:level="2"><nlm:aff id="aff103"><addr-line>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author><author><name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A." last="Kukull">Walter A. Kukull</name><affiliation wicri:level="4"><nlm:aff id="aff120"><addr-line>Department of Epidemiology, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><affiliation wicri:level="3"><nlm:aff id="aff35"><addr-line>CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNR-MAJ, Inserm U1079, Rouen University Hospital, 76031 France, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F." last="Powell">John F. Powell</name><affiliation><nlm:aff id="aff46"><addr-line>King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, United Kingom</addr-line></nlm:aff><wicri:noCountry code="subfield">United Kingom</wicri:noCountry></affiliation></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name><affiliation wicri:level="2"><nlm:aff id="aff121"><addr-line>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation wicri:level="3"><nlm:aff id="aff41"><addr-line>INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff122"><addr-line>Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L." last="Lunetta">Kathryn L. Lunetta</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kauwe, John S K" sort="Kauwe, John S K" uniqKey="Kauwe J" first="John S. K." last="Kauwe">John S. K. Kauwe</name><affiliation wicri:level="2"><nlm:aff id="aff123"><addr-line>Department of Biology, Brigham Young University, Provo, Utah, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, Brigham Young University, Provo, Utah</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation wicri:level="2"><nlm:aff id="aff124"><addr-line>Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff125"><addr-line>Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genetics Center and Div. of Epidemiology, University of Texas Health Sciences Center at Houston, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Riemenschneider, Matthias" sort="Riemenschneider, Matthias" uniqKey="Riemenschneider M" first="Matthias" last="Riemenschneider">Matthias Riemenschneider</name><affiliation wicri:level="1"><nlm:aff id="aff99"><addr-line>Department of Psychiatry, University Hospital, Saarland, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, University Hospital, Saarland</wicri:regionArea><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion><wicri:noRegion>Saarland</wicri:noRegion></affiliation></author><author><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name><affiliation wicri:level="3"><nlm:aff id="aff26"><addr-line>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Memory Clinic of Fundació ACE. Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff126"><addr-line>Hospital Universitari Vall d'Hebron - Institut de Recerca, Universitat Autònoma de Barcelona. (VHIR-UAB), Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitari Vall d'Hebron - Institut de Recerca, Universitat Autònoma de Barcelona. (VHIR-UAB), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name><affiliation wicri:level="1"><nlm:aff id="aff105"><addr-line>Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff106"><addr-line>Department of Neurology, Kuopio University Hospital, Kuopio, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Neurology, Kuopio University Hospital, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R." last="Martin">Eden R. Martin</name><affiliation wicri:level="2"><nlm:aff id="aff12"><addr-line>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff13"><addr-line>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="aff127"><addr-line>Department of Neurology, Medical University Graz, Graz, Austria</addr-line></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name><affiliation wicri:level="4"><nlm:aff id="aff85"><addr-line>Department of Psychiatry, Ludwig-Maximilians University, Munich, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Ludwig-Maximilians University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation wicri:level="3"><nlm:aff id="aff47"><addr-line>Inserm U897, Victor Segalen University, F-33076, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U897, Victor Segalen University, F-33076, Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff128"><addr-line>Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name><affiliation wicri:level="2"><nlm:aff id="aff27"><addr-line>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff28"><addr-line>Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="3"><nlm:aff id="aff129"><addr-line>Inserm U708, Victor Segalen University, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U708, Victor Segalen University, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="aff19"><addr-line>Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Departments of Epidemiology, Neurology and Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff20"><addr-line>Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name><affiliation wicri:level="3"><nlm:aff id="aff130"><addr-line>Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, and German Center for Neurodegenerative Diseases (DZNE, Bonn), Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Graff, Caroline" sort="Graff, Caroline" uniqKey="Graff C" first="Caroline" last="Graff">Caroline Graff</name><affiliation wicri:level="3"><nlm:aff id="aff113"><addr-line>Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff131"><addr-line>Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KIADRC, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KIADRC, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation wicri:level="4"><nlm:aff id="aff11"><addr-line>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff132"><addr-line>Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Group Health Research Institute, Group Health Cooperative, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name><affiliation wicri:level="2"><nlm:aff id="aff133"><addr-line>Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff134"><addr-line>Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff22"><addr-line>Fondation Jean Dausset- CEPH, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Fondation Jean Dausset- CEPH, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff135"><addr-line>McGill University and Génome Québec Innovation Centre, Montreal, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>McGill University and Génome Québec Innovation Centre, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name><affiliation wicri:level="2"><nlm:aff id="aff12"><addr-line>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff13"><addr-line>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation wicri:level="2"><nlm:aff id="aff111"><addr-line>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation wicri:level="1"><nlm:aff id="aff49"><addr-line>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff50"><addr-line>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff9"><addr-line>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff136"><addr-line>Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff137"><addr-line>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="3"><nlm:aff id="aff20"><addr-line>Netherlands Consortium for Healthy Aging, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff40"><addr-line>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</addr-line></nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff138"><addr-line>Center for Medical Systems Biology, Leiden, The Netherlands</addr-line></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Center for Medical Systems Biology, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ramirez, Alfredo" sort="Ramirez, Alfredo" uniqKey="Ramirez A" first="Alfredo" last="Ramirez">Alfredo Ramirez</name><affiliation wicri:level="3"><nlm:aff id="aff139"><addr-line>Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy and Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><nlm:aff id="aff18"><addr-line>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff140"><addr-line>The Framingham Heart Study, Framingham, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Framingham Heart Study, Framingham, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D." last="Schellenberg">Gerard D. Schellenberg</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Inserm U744, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm U744, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Université Lille 2, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille 2, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement><settlement type="city">Lille</settlement></placeName><orgName type="university">Université Lille 2</orgName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institut Pasteur de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff29"><addr-line>CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CNR-MAJ, Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff141"><addr-line>Centre Hospitalier Régional Universitaire de Lille, Lille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (genetics)</term><term>Carrier Proteins (genetics)</term><term>Case-Control Studies</term><term>Genome-Wide Association Study</term><term>Heat-Shock Proteins (genetics)</term><term>Humans</term><term>Polymorphism, Single Nucleotide</term><term>Receptors, Antigen, B-Cell (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Maladie d'Alzheimer (génétique)</term><term>Polymorphisme de nucléotide simple</term><term>Protéines de transport (génétique)</term><term>Protéines du choc thermique (génétique)</term><term>Récepteurs pour l'antigène des lymphocytes B (génétique)</term><term>Étude d'association pangénomique</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Carrier Proteins</term><term>Heat-Shock Proteins</term><term>Receptors, Antigen, B-Cell</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alzheimer Disease</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Maladie d'Alzheimer</term><term>Protéines de transport</term><term>Protéines du choc thermique</term><term>Récepteurs pour l'antigène des lymphocytes B</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Polymorphisme de nucléotide simple</term><term>Étude d'association pangénomique</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.</p></sec><sec><title>Principal Findings</title><p>In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (<italic>TP53INP1</italic>, p = 1.4×10<sup>−6</sup>) and 14 (<italic>IGHV1-67</italic> p = 7.9×10<sup>−8</sup>) which indexed novel susceptibility loci.</p></sec><sec><title>Significance</title><p>The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's 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(pays)</li><li>Islande</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Aquitaine</li><li>Arizona</li><li>Bavière</li><li>Californie</li><li>Canton de Zurich</li><li>Catalogne</li><li>Communauté de Madrid</li><li>District de Cologne</li><li>District de Haute-Bavière</li><li>East Middle Sweden</li><li>Floride</li><li>Grand Londres</li><li>Haute-Normandie</li><li>Hauts-de-France</li><li>Hollande-Méridionale</li><li>Illinois</li><li>Indiana</li><li>Languedoc-Roussillon</li><li>Latium</li><li>Lombardie</li><li>Maryland</li><li>Massachusetts</li><li>Missouri (État)</li><li>Nord-Pas-de-Calais</li><li>Nottinghamshire</li><li>Nouvelle-Aquitaine</li><li>Occitanie (région administrative)</li><li>Ohio</li><li>Ontario</li><li>Oxfordshire</li><li>Pennsylvanie</li><li>Province d'Anvers</li><li>Québec</li><li>Rhénanie-du-Nord-Westphalie</li><li>Région Normandie</li><li>Région flamande</li><li>Svealand</li><li>Tennessee</li><li>Texas</li><li>Toscane</li><li>Utah</li><li>Washington (État)</li><li>État de New York</li><li>État du Mississippi</li><li>Île-de-France</li></region><settlement><li>Anvers</li><li>Barcelone</li><li>Bonn</li><li>Bordeaux</li><li>Cambridge</li><li>Leyde</li><li>Lille</li><li>Londres</li><li>Madrid</li><li>Milan</li><li>Montpellier</li><li>Montréal</li><li>Munich</li><li>New York</li><li>Nottingham</li><li>Oxford</li><li>Paris</li><li>Pise</li><li>Pittsburgh</li><li>Rome</li><li>Rotterdam</li><li>Rouen</li><li>Saint-Louis (Missouri)</li><li>Seattle</li><li>Stockholm</li><li>Toronto</li><li>Uppsala</li><li>Zurich</li><li>Évry (Essonne)</li></settlement><orgName><li>Université Columbia</li><li>Université Lille 2</li><li>Université Louis-et-Maximilien de Munich</li><li>Université Pierre-et-Marie-Curie</li><li>Université autonome de Barcelone</li><li>Université d'Anvers</li><li>Université d'Oxford</li><li>Université d'Uppsala</li><li>Université de Cambridge</li><li>Université de Nottingham</li><li>Université de Pise</li><li>Université de Pittsburgh</li><li>Université de Toronto</li><li>Université de Washington</li><li>Université de Zurich</li><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><noCountry><name sortKey="Barberger Gateau, Pascale" sort="Barberger Gateau, Pascale" uniqKey="Barberger Gateau P" first="Pascale" last="Barberger-Gateau">Pascale Barberger-Gateau</name><name sortKey="Lovestone, Simon" sort="Lovestone, Simon" uniqKey="Lovestone S" first="Simon" last="Lovestone">Simon Lovestone</name><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F." last="Powell">John F. Powell</name><name sortKey="Proitsi, Petra" sort="Proitsi, Petra" uniqKey="Proitsi P" first="Petra" last="Proitsi">Petra Proitsi</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Escott Price, Valentina" sort="Escott Price, Valentina" uniqKey="Escott Price V" first="Valentina" last="Escott-Price">Valentina Escott-Price</name></noRegion><name sortKey="Bayer, Anthony" sort="Bayer, Anthony" uniqKey="Bayer A" first="Anthony" last="Bayer">Anthony Bayer</name><name sortKey="Brayne, Carol" sort="Brayne, Carol" uniqKey="Brayne C" first="Carol" last="Brayne">Carol Brayne</name><name sortKey="Brown, Kristelle" sort="Brown, Kristelle" uniqKey="Brown K" first="Kristelle" last="Brown">Kristelle Brown</name><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><name sortKey="Collinge, John" sort="Collinge, John" uniqKey="Collinge J" first="John" last="Collinge">John Collinge</name><name sortKey="Craig, David" sort="Craig, David" uniqKey="Craig D" first="David" last="Craig">David Craig</name><name sortKey="Denning, Nicola" sort="Denning, Nicola" uniqKey="Denning N" first="Nicola" last="Denning">Nicola Denning</name><name sortKey="Dunstan, Melanie L" sort="Dunstan, Melanie L" uniqKey="Dunstan M" first="Melanie L." last="Dunstan">Melanie L. Dunstan</name><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C." last="Fox">Nick C. Fox</name><name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name><name sortKey="George Hyslop, Peter St" sort="George Hyslop, Peter St" uniqKey="George Hyslop P" first="Peter St" last="George-Hyslop">Peter St George-Hyslop</name><name sortKey="Gerrish, Amy" sort="Gerrish, Amy" uniqKey="Gerrish A" first="Amy" last="Gerrish">Amy Gerrish</name><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><name sortKey="Harold, Denise" sort="Harold, Denise" uniqKey="Harold D" first="Denise" last="Harold">Denise Harold</name><name sortKey="Hollingworth, Paul" sort="Hollingworth, Paul" uniqKey="Hollingworth P" first="Paul" last="Hollingworth">Paul Hollingworth</name><name sortKey="Holmans, Peter" sort="Holmans, Peter" uniqKey="Holmans P" first="Peter" last="Holmans">Peter Holmans</name><name sortKey="Holmes, Clive" sort="Holmes, Clive" uniqKey="Holmes C" first="Clive" last="Holmes">Clive Holmes</name><name sortKey="Johnston, Janet A" sort="Johnston, Janet A" uniqKey="Johnston J" first="Janet A." last="Johnston">Janet A. Johnston</name><name sortKey="Jones, Lesley" sort="Jones, Lesley" uniqKey="Jones L" first="Lesley" last="Jones">Lesley Jones</name><name sortKey="Love, Seth" sort="Love, Seth" uniqKey="Love S" first="Seth" last="Love">Seth Love</name><name sortKey="Mcguinness, Bernadette" sort="Mcguinness, Bernadette" uniqKey="Mcguinness B" first="Bernadette" last="Mcguinness">Bernadette Mcguinness</name><name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name><name sortKey="Morgan, Kevin" sort="Morgan, Kevin" uniqKey="Morgan K" first="Kevin" last="Morgan">Kevin Morgan</name><name sortKey="O Donovan, Michael C" sort="O Donovan, Michael C" uniqKey="O Donovan M" first="Michael C." last="O'Donovan">Michael C. O'Donovan</name><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J." last="Owen">Michael J. Owen</name><name sortKey="Passmore, Peter" sort="Passmore, Peter" uniqKey="Passmore P" first="Peter" last="Passmore">Peter Passmore</name><name sortKey="Richards, Alexander" sort="Richards, Alexander" uniqKey="Richards A" first="Alexander" last="Richards">Alexander Richards</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><name sortKey="Rubinsztein, David C" sort="Rubinsztein, David C" uniqKey="Rubinsztein D" first="David C." last="Rubinsztein">David C. Rubinsztein</name><name sortKey="Sims, Rebecca" sort="Sims, Rebecca" uniqKey="Sims R" first="Rebecca" last="Sims">Rebecca Sims</name><name sortKey="Thomas, Charlene" sort="Thomas, Charlene" uniqKey="Thomas C" first="Charlene" last="Thomas">Charlene Thomas</name><name sortKey="Todd, Stephen" sort="Todd, Stephen" uniqKey="Todd S" first="Stephen" last="Todd">Stephen Todd</name><name sortKey="Vedernikov, Alexey" sort="Vedernikov, Alexey" uniqKey="Vedernikov A" first="Alexey" last="Vedernikov">Alexey Vedernikov</name><name sortKey="Vronskaya, Maria" sort="Vronskaya, Maria" uniqKey="Vronskaya M" first="Maria" last="Vronskaya">Maria Vronskaya</name><name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name></region><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><name sortKey="Bellenguez, Celine" sort="Bellenguez, Celine" uniqKey="Bellenguez C" first="Céline" last="Bellenguez">Céline Bellenguez</name><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><name sortKey="Bihoreau, Marie Therese" sort="Bihoreau, Marie Therese" uniqKey="Bihoreau M" first="Marie-Thérèse" last="Bihoreau">Marie-Thérèse Bihoreau</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name><name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><name sortKey="Fievet, Nathalie" sort="Fievet, Nathalie" uniqKey="Fievet N" first="Nathalie" last="Fiévet">Nathalie Fiévet</name><name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name><name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name><name sortKey="Grenier Boley, Benjamin" sort="Grenier Boley, Benjamin" uniqKey="Grenier Boley B" first="Benjamin" last="Grenier-Boley">Benjamin Grenier-Boley</name><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name><name sortKey="Hanon, Olivier" sort="Hanon, Olivier" uniqKey="Hanon O" first="Olivier" last="Hanon">Olivier Hanon</name><name sortKey="Kamatani, Yoichiro" sort="Kamatani, Yoichiro" uniqKey="Kamatani Y" first="Yoichiro" last="Kamatani">Yoichiro Kamatani</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><name sortKey="Letenneur, Luc" sort="Letenneur, Luc" uniqKey="Letenneur L" first="Luc" last="Letenneur">Luc Letenneur</name><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><name sortKey="Wallon, David" sort="Wallon, David" uniqKey="Wallon D" first="David" last="Wallon">David Wallon</name><name sortKey="Zelenika, Diana" sort="Zelenika, Diana" uniqKey="Zelenika D" first="Diana" last="Zelenika">Diana Zelenika</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Wang, Li San" sort="Wang, Li San" uniqKey="Wang L" first="Li-San" last="Wang">Li-San Wang</name></region><name sortKey="Baldwin, Clinton" sort="Baldwin, Clinton" uniqKey="Baldwin C" first="Clinton" last="Baldwin">Clinton Baldwin</name><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W." last="Beecham">Gary W. Beecham</name><name sortKey="Beecham, Gary W" sort="Beecham, Gary W" uniqKey="Beecham G" first="Gary W." last="Beecham">Gary W. Beecham</name><name sortKey="Beekly, Duane" sort="Beekly, Duane" uniqKey="Beekly D" first="Duane" last="Beekly">Duane Beekly</name><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><name sortKey="Blacker, Deborah" sort="Blacker, Deborah" uniqKey="Blacker D" first="Deborah" last="Blacker">Deborah Blacker</name><name sortKey="Blacker, Deborah" sort="Blacker, Deborah" uniqKey="Blacker D" first="Deborah" last="Blacker">Deborah Blacker</name><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name><name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name><name sortKey="Buxbaum, Joseph D" sort="Buxbaum, Joseph D" uniqKey="Buxbaum J" first="Joseph D." last="Buxbaum">Joseph D. Buxbaum</name><name sortKey="Cantwell, Laura B" sort="Cantwell, Laura B" uniqKey="Cantwell L" first="Laura B." last="Cantwell">Laura B. Cantwell</name><name sortKey="Carrasquillo, Minerva M" sort="Carrasquillo, Minerva M" uniqKey="Carrasquillo M" first="Minerva M." last="Carrasquillo">Minerva M. Carrasquillo</name><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><name sortKey="Crane, Paul K" sort="Crane, Paul K" uniqKey="Crane P" first="Paul K." last="Crane">Paul K. Crane</name><name sortKey="Cruchaga, Carlos" sort="Cruchaga, Carlos" uniqKey="Cruchaga C" first="Carlos" last="Cruchaga">Carlos Cruchaga</name><name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L." last="De Jager">Philip L. De Jager</name><name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L." last="De Jager">Philip L. De Jager</name><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><name sortKey="Evans, Denis" sort="Evans, Denis" uniqKey="Evans D" first="Denis" last="Evans">Denis Evans</name><name sortKey="Faber, Kelley M" sort="Faber, Kelley M" uniqKey="Faber K" first="Kelley M." last="Faber">Kelley M. Faber</name><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name><name sortKey="Farrer, Lindsay A" sort="Farrer, Lindsay A" uniqKey="Farrer L" first="Lindsay A." last="Farrer">Lindsay A. Farrer</name><name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L." last="Fitzpatrick">Annette L. Fitzpatrick</name><name sortKey="Fitzpatrick, Annette L" sort="Fitzpatrick, Annette L" uniqKey="Fitzpatrick A" first="Annette L." last="Fitzpatrick">Annette L. Fitzpatrick</name><name sortKey="Foroud, Tatiana M" sort="Foroud, Tatiana M" uniqKey="Foroud T" first="Tatiana M." last="Foroud">Tatiana M. Foroud</name><name sortKey="Goate, Alison M" sort="Goate, Alison M" uniqKey="Goate A" first="Alison M." last="Goate">Alison M. Goate</name><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name><name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L." last="Haines">Jonathan L. Haines</name><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><name sortKey="Hamilton Nelson, Kara L" sort="Hamilton Nelson, Kara L" uniqKey="Hamilton Nelson K" first="Kara L." last="Hamilton-Nelson">Kara L. Hamilton-Nelson</name><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><name sortKey="Huentelman, Matthew J" sort="Huentelman, Matthew J" uniqKey="Huentelman M" first="Matthew J." last="Huentelman">Matthew J. Huentelman</name><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name><name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name><name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name><name sortKey="Jun, Gyungah" sort="Jun, Gyungah" uniqKey="Jun G" first="Gyungah" last="Jun">Gyungah Jun</name><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name><name sortKey="Kamboh, M Ilyas" sort="Kamboh, M Ilyas" uniqKey="Kamboh M" first="M. Ilyas" last="Kamboh">M. Ilyas Kamboh</name><name sortKey="Kauwe, John S K" sort="Kauwe, John S K" uniqKey="Kauwe J" first="John S. K." last="Kauwe">John S. K. Kauwe</name><name sortKey="Kukull, Walter A" sort="Kukull, Walter A" uniqKey="Kukull W" first="Walter A." last="Kukull">Walter A. Kukull</name><name sortKey="Kunkle, Brian" sort="Kunkle, Brian" uniqKey="Kunkle B" first="Brian" last="Kunkle">Brian Kunkle</name><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B." last="Larson">Eric B. Larson</name><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B." last="Larson">Eric B. Larson</name><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><name sortKey="Lin, Chiao Feng" sort="Lin, Chiao Feng" uniqKey="Lin C" first="Chiao-Feng" last="Lin">Chiao-Feng Lin</name><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name><name sortKey="Lunetta, Kathryn L" sort="Lunetta, Kathryn L" uniqKey="Lunetta K" first="Kathryn L." last="Lunetta">Kathryn L. Lunetta</name><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R." last="Martin">Eden R. Martin</name><name sortKey="Martin, Eden R" sort="Martin, Eden R" uniqKey="Martin E" first="Eden R." last="Martin">Eden R. Martin</name><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name><name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J." last="Montine">Thomas J. Montine</name><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name><name sortKey="Myers, Amanda J" sort="Myers, Amanda J" uniqKey="Myers A" first="Amanda J." last="Myers">Amanda J. Myers</name><name sortKey="Naj, Adam C" sort="Naj, Adam C" uniqKey="Naj A" first="Adam C." last="Naj">Adam C. Naj</name><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name><name sortKey="Pericak Vance, Margaret A" sort="Pericak Vance, Margaret A" uniqKey="Pericak Vance M" first="Margaret A." last="Pericak-Vance">Margaret A. Pericak-Vance</name><name sortKey="Perry, William" sort="Perry, William" uniqKey="Perry W" first="William" last="Perry">William Perry</name><name sortKey="Perry, William" sort="Perry, William" uniqKey="Perry W" first="William" last="Perry">William Perry</name><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><name sortKey="Reitz, Christiane" sort="Reitz, Christiane" uniqKey="Reitz C" first="Christiane" last="Reitz">Christiane Reitz</name><name sortKey="Reitz, Christiane" sort="Reitz, Christiane" uniqKey="Reitz C" first="Christiane" last="Reitz">Christiane Reitz</name><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><name sortKey="Schellenberg, Gerard D" sort="Schellenberg, Gerard D" uniqKey="Schellenberg G" first="Gerard D." last="Schellenberg">Gerard D. Schellenberg</name><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><name sortKey="Thornton Wells, Tricia A" sort="Thornton Wells, Tricia A" uniqKey="Thornton Wells T" first="Tricia A." last="Thornton-Wells">Tricia A. Thornton-Wells</name><name sortKey="Tsuang, Debby W" sort="Tsuang, Debby W" uniqKey="Tsuang D" first="Debby W." last="Tsuang">Debby W. Tsuang</name><name sortKey="Valladares, Otto" sort="Valladares, Otto" uniqKey="Valladares O" first="Otto" last="Valladares">Otto Valladares</name><name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N." last="Vardarajan">Badri N. Vardarajan</name><name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N." last="Vardarajan">Badri N. Vardarajan</name><name sortKey="Vardarajan, Badri N" sort="Vardarajan, Badri N" uniqKey="Vardarajan B" first="Badri N." last="Vardarajan">Badri N. Vardarajan</name><name sortKey="Younkin, Steven G" sort="Younkin, Steven G" uniqKey="Younkin S" first="Steven G." last="Younkin">Steven G. Younkin</name><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><name sortKey="Zou, Fanggeng" sort="Zou, Fanggeng" uniqKey="Zou F" first="Fanggeng" last="Zou">Fanggeng Zou</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name></region><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renee F. A. G." last="De Bruijn">Renee F. A. G. De Bruijn</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Russo, Giancarlo" sort="Russo, Giancarlo" uniqKey="Russo G" first="Giancarlo" last="Russo">Giancarlo Russo</name></region></country><country name="Islande"><noRegion><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name></noRegion><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V." last="Jonsson">Palmi V. Jonsson</name><name sortKey="Jonsson, Palmi V" sort="Jonsson, Palmi V" uniqKey="Jonsson P" first="Palmi V." last="Jonsson">Palmi V. Jonsson</name><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. 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Nöthen</name><name sortKey="Pichler, Sabrina" sort="Pichler, Sabrina" uniqKey="Pichler S" first="Sabrina" last="Pichler">Sabrina Pichler</name><name sortKey="Ramirez, Alfredo" sort="Ramirez, Alfredo" uniqKey="Ramirez A" first="Alfredo" last="Ramirez">Alfredo Ramirez</name><name sortKey="Riemenschneider, Matthias" sort="Riemenschneider, Matthias" uniqKey="Riemenschneider M" first="Matthias" last="Riemenschneider">Matthias Riemenschneider</name><name sortKey="Rujescu, Dan" sort="Rujescu, Dan" uniqKey="Rujescu D" first="Dan" last="Rujescu">Dan Rujescu</name></country><country name="Belgique"><noRegion><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name></noRegion><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><name sortKey="Bettens, Karolien" sort="Bettens, Karolien" uniqKey="Bettens K" first="Karolien" last="Bettens">Karolien Bettens</name><name sortKey="Sleegers, Kristel" sort="Sleegers, Kristel" uniqKey="Sleegers K" first="Kristel" last="Sleegers">Kristel Sleegers</name><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Keller, Lina" sort="Keller, Lina" uniqKey="Keller L" first="Lina" last="Keller">Lina Keller</name></region><name sortKey="Fratiglioni, Laura" sort="Fratiglioni, Laura" uniqKey="Fratiglioni L" first="Laura" last="Fratiglioni">Laura Fratiglioni</name><name sortKey="Fratiglioni, Laura" sort="Fratiglioni, Laura" uniqKey="Fratiglioni L" first="Laura" last="Fratiglioni">Laura Fratiglioni</name><name sortKey="Graff, Caroline" sort="Graff, Caroline" uniqKey="Graff C" first="Caroline" last="Graff">Caroline Graff</name><name sortKey="Graff, Caroline" sort="Graff, Caroline" uniqKey="Graff C" first="Caroline" last="Graff">Caroline Graff</name><name sortKey="Ingelsson, Martin" sort="Ingelsson, Martin" uniqKey="Ingelsson M" first="Martin" last="Ingelsson">Martin Ingelsson</name><name sortKey="Lannfelt, Lars" sort="Lannfelt, Lars" uniqKey="Lannfelt L" first="Lars" last="Lannfelt">Lars Lannfelt</name></country><country name="Canada"><region name="Ontario"><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name></region><name sortKey="George Hyslop, Peter St" sort="George Hyslop, Peter St" uniqKey="George Hyslop P" first="Peter St" last="George-Hyslop">Peter St George-Hyslop</name><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name></country><country name="Grèce"><noRegion><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name></noRegion></country><country name="Italie"><region name="Latium"><name sortKey="Bossu, Paola" sort="Bossu, Paola" uniqKey="Bossu P" first="Paola" last="Bossù">Paola Bossù</name></region><name sortKey="Bonuccelli, Ubaldo" sort="Bonuccelli, Ubaldo" uniqKey="Bonuccelli U" first="Ubaldo" last="Bonuccelli">Ubaldo Bonuccelli</name><name sortKey="Bosco, Paolo" sort="Bosco, Paolo" uniqKey="Bosco P" first="Paolo" last="Bosco">Paolo Bosco</name><name sortKey="Caffarra, Paolo" sort="Caffarra, Paolo" uniqKey="Caffarra P" first="Paolo" last="Caffarra">Paolo Caffarra</name><name sortKey="Caffarra, Paolo" sort="Caffarra, Paolo" uniqKey="Caffarra P" first="Paolo" last="Caffarra">Paolo Caffarra</name><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name><name sortKey="Mancuso, Michelangelo" sort="Mancuso, Michelangelo" uniqKey="Mancuso M" first="Michelangelo" last="Mancuso">Michelangelo Mancuso</name><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><name sortKey="Nacmias, Benedetta" sort="Nacmias, Benedetta" uniqKey="Nacmias B" first="Benedetta" last="Nacmias">Benedetta Nacmias</name><name sortKey="Panza, Francesco" sort="Panza, Francesco" uniqKey="Panza F" first="Francesco" last="Panza">Francesco Panza</name><name sortKey="Pilotto, Alberto" sort="Pilotto, Alberto" uniqKey="Pilotto A" first="Alberto" last="Pilotto">Alberto Pilotto</name><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name><name sortKey="Siciliano, Gabriele" sort="Siciliano, Gabriele" uniqKey="Siciliano G" first="Gabriele" last="Siciliano">Gabriele Siciliano</name><name sortKey="Solfrizzi, Vincenzo" sort="Solfrizzi, Vincenzo" uniqKey="Solfrizzi V" first="Vincenzo" last="Solfrizzi">Vincenzo Solfrizzi</name><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><name sortKey="Sorbi, Sandro" sort="Sorbi, Sandro" uniqKey="Sorbi S" first="Sandro" last="Sorbi">Sandro Sorbi</name><name sortKey="Spalletta, Gianfranco" sort="Spalletta, Gianfranco" uniqKey="Spalletta G" first="Gianfranco" last="Spalletta">Gianfranco Spalletta</name><name sortKey="Zompo, Maria Del" sort="Zompo, Maria Del" uniqKey="Zompo M" first="Maria Del" last="Zompo">Maria Del Zompo</name></country><country name="Finlande"><noRegion><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name></noRegion><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name><name sortKey="Hiltunen, Mikko" sort="Hiltunen, Mikko" uniqKey="Hiltunen M" first="Mikko" last="Hiltunen">Mikko Hiltunen</name><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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